1. 清新电源首页
  2. 学术动态
  3. 博采百家
  4. AdvancedScienceNews

【EMBO系列】EMBO Neurodegeneration2017选刊

【EMBO系列】EMBO Neurodegeneration2017选刊


这期EMBO选刊以神经退行性疾病为主题。所选文章涵盖正常情况或以及疾病条件下脑代谢的调节,阿尔茨海默氏病的淀粉样蛋白假说,C9orf72 ALS / FTD biomarker,线粒体和小胶质细胞在神经变性中的作用等方面


长按下方二维码可直达原文页面。


FEATURED ARTICLES

【EMBO系列】EMBO Neurodegeneration2017选刊

【EMBO系列】EMBO Neurodegeneration2017选刊

【EMBO系列】EMBO Neurodegeneration2017选刊

Brain metabolism in health, aging, and neurodegeneration
Simonetta Camandola and Mark P Mattson

As part of our metabolism focus, this review provides an overview of cellular and molecular mechanisms that regulate brain energy metabolism and how such mechanisms are altered during aging and disease.

The EMBO Journal (2017) e201695810
DOI: 10.15252/embj.201695810

【EMBO系列】EMBO Neurodegeneration2017选刊

【EMBO系列】EMBO Neurodegeneration2017选刊

【EMBO系列】EMBO Neurodegeneration2017选刊

Amyloid hypothesis of Alzheimer’s disease at 25 years
Dennis J Selkoe and John Hardy

This review by Selkoe and Hardy provides a comprehensive and commanding analysis on the causative role of Abeta and the amyloid cascade hypothesis in the pathology of Alzheimer’s disease.

The EMBO Molecular Medicine (2016) 8(6), 595-608
DOI 10.15252/emmm.201606210

【EMBO系列】EMBO Neurodegeneration2017选刊

【EMBO系列】EMBO Neurodegeneration2017选刊

【EMBO系列】EMBO Neurodegeneration2017选刊

Poly‐GP in cerebrospinal fluid links C9orf72‐associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD
Carina Lehmer, Patrick Oeckl, Jochen H Weishaupt, Alexander E Volk, Janine Diehl‐Schmid, Matthias L Schroeter, Martin Lauer, Johannes Kornhuber, Johannes Levin, Klaus Fassbender, Bernhard Landwehrmeyer, German Consortium for Frontotemporal Lobar Degeneration, Martin H Schludi, Thomas Arzberger, Elisabeth Kremmer, Andrew Flatley, Regina Feederle, Petra Steinacker, Patrick Weydt, Albert C Ludolph, Dieter Edbauer, Markus Otto

The C9orf72 hexanucleotide repeat expansion causing amyotrophic lateral sclerosis and frontotemporal dementia is translated into five dipeptide repeat (DPR) proteins, including poly-GP. Analysis of poly-GP levels in the CSF of patients and presymptomatic carriers support an early role of DPRs in pathogenesis.

EMBO Molecular Medicine (2017) e201607486
DOI 10.15252/emmm.201607486

【EMBO系列】EMBO Neurodegeneration2017选刊

【EMBO系列】EMBO Neurodegeneration2017选刊

【EMBO系列】EMBO Neurodegeneration2017选刊

FKBP8 recruits LC3A to mediate Parkin‐independent mitophagy
Zambarlal Bhujabal, Åsa B Birgisdottir, Eva Sjøttem, Hanne B Brenne, Aud Øvervatn, Sabrina Habisov, Vladimir Kirkin, Trond Lamark, Terje Johansen

FKBP8 (also called FKBP38) is a novel mitophagy receptor that selectively recruits LC3A to damaged mitochondria to mediate Parkin-independent degradation of mitochondria by autophagy. The anti-apoptotic FKBP8 itself escapes degradation to ensure cell survival.

EMBO reports (2017) e201643147
DOI 10.15252/embr.201643147

【EMBO系列】EMBO Neurodegeneration2017选刊

【EMBO系列】EMBO Neurodegeneration2017选刊

【EMBO系列】EMBO Neurodegeneration2017选刊

Young microglia restore amyloid plaque clearance of aged microglia
Anna Daria, Alessio Colombo, Gemma Llovera, Heike Hampel, Michael Willem, Arthur Liesz, Christian Haass and Sabina Tahirovic

Impaired phagocytic function of aged microglia can be rescued via GM‐CSF secretion from co‐cultured young microglia in amyloid‐bearing organotypic tissue.

The EMBO Journal (2017) 36(5): 583-603
DOI 10.15252/embj.201694591

互动关注


Wiley Advanced Science News官方微信平台

如希望发表科研新闻或申请信息分享,请联系:ASNChina@wiley.com

关注方式:微信右上角添加朋友—公众号—搜索“AdvancedScienceNews”或下方长按识别二维码。【EMBO系列】EMBO Neurodegeneration2017选刊


本站非明确注明的内容,皆来自转载,本文观点不代表清新电源立场。

发表评论

登录后才能评论